, maculopapular exanthema and angioedema of upper and lower limbs. No analytical changes were found in the acute phase. He was treated with intravenous corticosteroid and antihistamines and, 4 days after complete recovery, the drug wasre-introduced with reproducible signs and symptoms arising 12 h after the intake of 100 mg of modafinil. Because this was the only therapeutic option for the patient