Tos effect. This observation suggests that the suppressive effect of asbestos on TUSC2 expression is mediated via ROS. Indeed, generation of ROS by asbestos was documented in many studies [25]. A yet another source of ROS that may keep the TUSC2 level down in normal and malignant tissues are inflammatory cells attracted to the site of asbestos lodging [31]. We previously showed that TUSC2 is expre