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Hose with associated bacteremia) with linezolid often used as a first-line treatment. Early reports of linezolid resistant enterococci occurred predominantly in immunocompromised hosts who resided in an ICU [68].New antifungal drugsPolyclonal intravenous immunoglobulins have been suggested to be beneficial during sepsis by modulating the immune response and neutralizing bacterial endo and exotoxin
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With decreased porin production after the use of carbapenems [62]. Enterobacteriaceae that produce Klebsiella pneumonia- To date, posaconazole is only available in oral suspension. A study evaluating the pharmacokinetics and adverse effects of an intravenous formulation of posaconazole is currently being completed (ClinicalTrials.gov. Pharmacokinetics, safety, and tolerability of intravenous posac
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M the infectious diseases working party of the German Society of Hematology and Oncology [10] for the management of sepsis in neutropenic patient recommend the use of norepinephrine as the drug of choice if a sufficient mean arterial pressure (> 65 mmHg) cannot be achieved by fluid resuscitation, associated with dobutamine in case of sepsis-related myocardial depression . Moreover, D. Schnell and
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Fection, allo-immunization and transfusion-related acute lung injury (TRALI) syndrome. Therefore, granulocyte transfusions are not recommended in routine use and should be avoided in ICU.Intravenous immunoglobulincarbapenemases (KPCs) that confer resistance to all lactams, are now reported worldwide and may require treatment with colistin or tigecycline [65,66]. Fluoroquinolone exposure is associa
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Eared not to be influenced. In ICU, in a retrospective study of 28 neutropenic patients who received G-CSF compared to 33 patients who did notZafrani and Azoulay BMC Infectious Diseases 2014, 14:512 http://www.biomedcentral.com/1471-2334/14/Page 6 ofreceived G-CSF, Gruson et al. did not found any difference in terms of clinical outcome and occurrence of nosocomial infections [56]. Moreover, as men
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Ing trends and recent advancesMultidrug resistant bacteriaMultidrug-resistant bacteria have become more prevalent among neutropenic patients because of their greater time exposure to the health-care environment and selective pressure from prophylactic and therapeutic antimicrobial drugs. In neutropenic patient, among Gram-negative bacteria, Pseudomonas aeruginosa, Acinetobacter species, Escherichi
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Fection, allo-immunization and transfusion-related acute lung injury (TRALI) syndrome. Therefore, granulocyte transfusions are not recommended in routine use and should be avoided in ICU.Intravenous immunoglobulincarbapenemases (KPCs) that confer resistance to all lactams, are now reported worldwide and may require treatment with colistin or tigecycline [65,66]. Fluoroquinolone exposure is associa
1
Fection, allo-immunization and transfusion-related acute lung injury (TRALI) syndrome. Therefore, granulocyte transfusions are not recommended in routine use and should be avoided in ICU.Intravenous immunoglobulincarbapenemases (KPCs) that confer resistance to all lactams, are now reported worldwide and may require treatment with colistin or tigecycline [65,66]. Fluoroquinolone exposure is associa